The new British Prime Minister Theresa May announced six members of her cabinet today.

Amid a sweeping crackdown on dissent in Egypt, security forces have forcibly disappeared hundreds of people since the beginning of 2015, according to a new report from Amnesty International.

It's an "unprecedented spike," the group says, with an average of three or four people disappeared every day.

The Republican Party, as it prepares for its convention next week has checked off item No. 1 on its housekeeping list — drafting a party platform. The document reflects the conservative views of its authors, many of whom are party activists. So don't look for any concessions to changing views among the broader public on key social issues.

Many public figures who took to Twitter and Facebook following the murder of five police officers in Dallas have faced public blowback and, in some cases, found their employers less than forgiving about inflammatory and sometimes hateful online comments.

As Venezuela unravels — with shortages of food and medicine, as well as runaway inflation — President Nicolas Maduro is increasingly unpopular. But he's still holding onto power.

"The truth in Venezuela is there is real hunger. We are hungry," says a man who has invited me into his house in the northwestern city of Maracaibo, but doesn't want his name used for fear of reprisals by the government.

The wiry man paces angrily as he speaks. It wasn't always this way, he says, showing how loose his pants are now.

Ask a typical teenage girl about the latest slang and girl crushes and you might get answers like "spilling the tea" and Taylor Swift. But at the Girl Up Leadership Summit in Washington, D.C., the answers were "intersectional feminism" — the idea that there's no one-size-fits-all definition of feminism — and U.N. climate chief Christiana Figueres.

Copyright 2016 NPR. To see more, visit http://www.npr.org/.

Copyright 2016 NPR. To see more, visit http://www.npr.org/.

Copyright 2016 NPR. To see more, visit http://www.npr.org/.

Copyright 2016 NPR. To see more, visit http://www.npr.org/.

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What Makes Good Bacteria Go Bad? It's Not Them, It's You

Aug 8, 2013
Originally published on August 8, 2013 10:01 am

Imagine a friend of a friend brings his family to stay with you — his family of tiny survivalists. For weeks or months you all live quietly side by side with no problems. You share meals. Your kids play together.

Then one day you get sick — maybe felled by a bad cold or the flu. Suddenly certain the end is near, your jittery houseguest breaks out an armory's worth of chemical weapons. He abandons his community to save himself and hunt for a new home, wreaking havoc on the way out the door.

That's essentially the story line microbiologists in Buffalo, N.Y., have now worked out for why colonies of Streptococcus pneumoniae bacteria (aka pneumococcus) can camp out happily and harmlessly for months at a time in the nose and throats of humans, then abruptly turn on their hosts. The germs sometimes trigger painful earaches or even meningitis in kids, and often pneumonia in the elderly and others with weak immune systems.

It's no small problem. The World Health Organization calls diseases triggered by the microbe "a major global public health problem." In 2000 alone pneumococcus provoked an estimated 14.5 million bouts of serious illness worldwide, according to the WHO, and killed perhaps 826,000 children under the age of 5.

"We were interested in getting at the mechanism — why these bacteria would suddenly migrate from the throat to the middle ear, lungs, or bloodstream which are normally sterile," Anders Hakansson, a microbiologist at the State University of New York at Buffalo, tells Shots. "We wanted to know why people get sick." He thinks he and his colleagues may have figured it out.

In a cool bit of science they recently published in the journal mBio, the researchers describe how they created a microbial community in a lab dish that mimics what happens in the lining of the human nose and upper throat.

Normally S. pneumoniae bacteria organize themselves there into a stable and highly structured slick, or biofilm, with other microbes, Hakansson says. "You'll see towers growing up," he says, "with channels coming down for water and nutrients," all layered atop the human cells.

But when the scientists added a pinch of flu virus to the mix – or in several other ways tweaked the little ecosystem to mimic what happens to the body when we catch the flu – the bacteria changed dramatically.

Increasing the colony's temperature (mimicking the fever of flu), for example, or adding the stress-linked hormone norepinephrine prompted some of the microbes to abruptly break off from the community.

And as they dispersed, the bacteria switched on a set of genes that made each one far more virulent when the scientists squirted them into mice. (In contrast, squirts of bacteria taken from the stable colonies of S. pneumoniae migrated to the animals' throats and harmlessly set up shop there, just as they usually do in people.)

Hakansson says he suspects, though can't say for certain, that the lungs and middle ears are just cul-de-sacs where the activated, pioneering bacteria get stuck during their hunt for a new home in a healthier host. The fact that their human host gets very sick or even dies from such infections isn't good for the bacteria either.

At any given time, between 25 and 40 percent of children under age 5 are colonized with the bacteria, Hakansson says, and between 8 and 15 percent of adults. Typically, these bacterial campsites persist for a few days, weeks or months, and don't produce symptoms. "They don't mean to make us sick," Hakansson says.

Find that cold comfort? You can boost your defenses. The Centers for Disease Control and Prevention recommends that all children under age 5, adults with certain risk factors, and all adults 65 or older get vaccinated against the microbe.

Copyright 2013 NPR. To see more, visit http://www.npr.org/.