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Convention Countdown

The Republican National Convention is in 4 days in Cleveland.

The Democratic National Convention is in 11 days in Philadelphia.

NASA has released the first picture of Jupiter taken since the Juno spacecraft went into orbit around the planet on July 4.

The picture was taken on July 10. Juno was 2.7 million miles from Jupiter at the time. The color image shows some of the atmospheric features of the planet, including the giant red spot. You can also see three of Jupiter's moons in the picture: Io, Europa and Ganymede.

The Senate is set to approve a bill intended to change the way police and health care workers treat people struggling with opioid addictions.

My husband and I once took great pleasure in preparing meals from scratch. We made pizza dough and sauce. We baked bread. We churned ice cream.

Then we became parents.

Now there are some weeks when pre-chopped veggies and a rotisserie chicken are the only things between us and five nights of Chipotle.

Parents are busy. For some of us, figuring out how to get dinner on the table is a daily struggle. So I reached out to food experts, parents and nutritionists for help. Here is some of their (and my) best advice for making weeknight meals happen.

"O Canada," the national anthem of our neighbors up north, comes in two official versions — English and French. They share a melody, but differ in meaning.

Let the record show: neither version of those lyrics contains the phrase "all lives matter."

But at the 2016 All-Star Game, the song got an unexpected edit.

At Petco Park in San Diego, one member of the Canadian singing group The Tenors — by himself, according to the other members of the group — revised the anthem.

School's out, and a lot of parents are getting through the long summer days with extra helpings of digital devices.

How should we feel about that?

Police in Baton Rouge say they have arrested three people who stole guns with the goal of killing police officers. They are still looking for a fourth suspect in the alleged plot, NPR's Greg Allen reports.

"Police say the thefts were at a Baton Rouge pawn shop early Saturday morning," Greg says. "One person was arrested at the scene. Since then, two others have been arrested and six of the eight stolen handguns have been recovered. Police are still looking for one other man."

A 13-year-old boy is among those arrested, Greg says.

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After an international tribunal invalidated Beijing's claims to the South China Sea, Chinese authorities have declared in no uncertain terms that they will be ignoring the ruling.

The Philippines brought the case to the Permanent Court of Arbitration in The Hague, objecting to China's claims to maritime rights in the disputed waters. The tribunal agreed that China had no legal authority to claim the waters and was infringing on the sovereign rights of the Philippines.

Donald Trump is firing back at Supreme Court Justice Ruth Bader Ginsburg after she disparaged him in several media interviews. He tweeted late Tuesday that she "has embarrassed all" with her "very dumb political statements" about the candidate. Trump ended his tweet with "Her mind is shot - resign!":


Kids Of Older Fathers Likelier To Have Genetic Ailments

Aug 22, 2012
Originally published on August 27, 2012 9:57 am

Scientists have found solid evidence that older men have more random mutations in their sperm cells. They're warning that can cause autism, schizophrenia and a long list of other genetic diseases in their offspring.

The new report, in the journal Nature, comes from deCODE Genetics, an Icelandic firm that studied the entire genomes of 78 families involving 219 individuals.

It's not the first time researchers have suggested the father's age is linked to increased genetic risk. The hypothesis goes back nearly a century. But the Icelandic researchers have shown that the father's contribution to genetic disorders is far higher than the mother's.

It makes sense. Men churn out around 200 million sperm a day, providing 200 million daily opportunities for spontaneous "point" mutations when genes get mis-copied. But once women reach puberty, they don't make new egg cells, so their rate of mutations – usually errors in chromosomes, or whole groups of genes – is fixed.

And sure enough, the new paper shows that the rate of new mutations rises steadily in men's germ cells – doubling every 16 1/2 years. Men in their 20s harbor about 25 random mutations, while a 40-year-old man has 65 mutations on average.

Women have about 15 mutations on average whatever their age.

"This is the first time we've seen absolute empirical proof that it's really the age of the father that's responsible for an increase in the mutation rate in the offspring," Dr. Mark Daly told Shots. Daly, who was not involved with the new research,is with the Massachusetts General Hospital Center for Human Genetic Research.

Kari Stefansson of deCODE Genetics says the father's age accounts for 97 percent of the new, or spontaneous, mutations found in his children's genes.

"This is astonishing and extremely important," Stefansson told Shots, "both from the point of view of human evolution and also from the point of view of diseases to which new mutations contribute."

Prominent among those diseases are brain disorders such as autism and schizophrenia. That's because about half of all human genes code for proteins important in brain function.

The Icelanders note that other studies have found the risk of schizophrenia and autism spectrum disorders increases with the father's age at conception.

Stefansson says the increasing age of fathers may help explain why. He notes that the age of fatherhood has been increasing in Iceland since 1980, and says that has brought a 17 percent increase in new mutations among their offspring.

"That is a huge increase from an evolutionary point of view, and it's also a very substantial increase when it comes to the probability of disease-causing mutations," he says. "So I don't think that the increase in the age of fathers at conception has been inconsequential."

But he doesn't have data on autism in Iceland to make the connection. And he says the contribution of paternal age to the problem will have to be sorted out from the cases of autism caused by inherited genes, as opposed to new, spontaneous mutations.

"I think we have a lot more research to do before we understand precisely how an increase in paternal age contributes to the increasing incidence of autism," Daly of Massachusetts General says.

One cautionary factoid: While the age of fatherhood has increased more than 30 percent since 1980, autism diagnoses have gone up 10-fold. So it doesn't look like paternal age is the only explanation.

The new research is bound to raise questions about whether older men and their partners should worry about the genetic risk they pose to their offspring.

Reassuringly, experts say most point mutations are harmless. But Alexey Kondrashov of the Universityof Michigan notes in an accompanying Nature commentary that 10 percent of them are deleterious. He suggests freezing sperm for later use "could be a wise individual decision" for a young man.

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