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Alzheimer's Drug Dials Back Deafness In Mice

Jan 9, 2013
Originally published on April 20, 2016 1:36 pm

If you've spent years CRANKING YOUR MUSIC UP TO 11, this item's for you.

A drug developed for Alzheimer's disease can partially reverse hearing loss caused by exposure to extremely loud sounds, an international team reports in the journal Neuron.

Before you go back to rocking the house with your Van Halen collection, though, consider that the drug has only been tried in mice so far. And it has never been approved for human use.

Even so, the result "is real and a step in the right direction," says Ed Rubel, a researcher at the University of Washington who wasn't involved in the study and has spent decades studying ways to restore hearing.

Loud noises cause hearing loss by injuring or killing hair cells, cells in the inner ear that transform sounds into electrical signals that are sent to the brain.

"The unusual thing about these hair cells is that what you're born with is what you have throughout life," says Harvard's Albert Edge, who is also a researcher at Massachusetts Eye and Ear and one of the study's authors. "That's why deafness tends to be permanent."

Hair cells can be lost to diseases, after taking certain medications, or as a part of normal aging. And hearing specialists are seeing a new group of relatively young people who have lost hair cells, Edge says.

"What's important in our society right now are a lot of the soldiers coming back from overseas who have been exposed to even a single loud noise which can seriously damage hearing," he says.

Tens of thousands of veterans have hearing loss because they were in a firefight or near a bomb blast that produced a sound many times louder than even the loudest rock concert.

Because permanent hearing loss is so common in people, scientists have been studying species in which deafness is only temporary. Fish, for example, can grow new hair cells to replace damaged ones. And in the 1980s researchers showed that that birds — warm-blooded creatures that are more like us — had the same ability.

"You can, in fact, deafen a chick, for example, and over the course of a couple of weeks they completely recover their hearing and the hair cells grow back, Edge says.

That finding got scientists looking for a way to accomplish the same feat in mammals, which don't naturally regrow hair cells. The study in Neuron suggests they've partially succeeded, Edge says.

Edge's team took a bunch of mice and exposed one ear to a very loud noise. Then they looked to see whether the ear was still producing electrical signals in response to a sound. There wasn't.

"Their ear is essentially dead," Edge says.

Next, the team administered an experimental drug known as a gamma secretase inhibitor to the inner ear. Gamma secretase inhibitors were developed to treat Alzheimer's disease, but haven't worked out for that purpose. The drugs never made it to the market for humans — or mice — so you can't go ask your doctor for a presciption.

These drugs have an interesting side effect, though, Edge says. In mice, they can cause so-called support cells from the inner ear to transform into hair cells.

"And to our delight these hair cells were functioning hair cells that improved the hearing of the animal," he says.

Edge says this shows it IS possible to grow new hair cells in a mammal. And because mice and humans have very similar hearing systems, he says, the approach is likely to work in people too.

It's not a complete cure, though. The mice got only about 20 percent of their hearing back, and still couldn't hear certain sound frequencies, Edge says.

Gamma secretase inhibitors are just one approach to restoring hearing, says Rubel, one of the scientists who discovered that birds could regenerate hair cells. Other approaches being tried include gene therapy, he says.

"I'm hugely optimistic, Rubel says. "There's no question that sometime in the future we will restore hearing in humans through regeneration."

It may take a couple more decades, though, Rubel says.

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